About   Help   FAQ
Gli1tm3(cre/ERT2)Alj
Targeted Allele Detail
Nomenclature
Symbol: Gli1tm3(cre/ERT2)Alj
Name: GLI-Kruppel family member GLI1; targeted mutation 3, Alexandra L Joyner
MGI ID: MGI:3053957
Synonyms: Gli1CreER, Gli1CreERT2, Gli1-CreERT2, Gli1tm3(cre/ERT2)Alj, Gli1tm3(cre/ESR1)Alj
Gene: Gli1  Location: Chr10:127329882-127341579 bp, - strand  Genetic Position: Chr10, 74.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92507
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsCreERT2 cDNA and a floxed neo were inserted into the 5' UTR of the first coding exon. Crossing with mice expressing Cre removed the floxed neo. Cre expression in mice carrying this allele is induced by treating the mice with tamoxifen. (J:92507)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gli1     Summary of all recombinase alleles driven by Gli1. Comparative matrix view of recombinase activities
 

Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gli1 Mutation:  10 strains or lines available
References
Original:  J:92507 Ahn S, et al., Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning. Cell. 2004 Aug 20;118(4):505-16
All:  100 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory