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Nr5a2tm1Auw
Targeted Allele Detail
Nomenclature
Symbol: Nr5a2tm1Auw
Name: nuclear receptor subfamily 5, group A, member 2; targeted mutation 1, Johan Auwerx
MGI ID: MGI:3053912
Synonyms: LRH-1-
Gene: Nr5a2  Location: Chr1:136842571-136960448 bp, - strand  Genetic Position: Chr1, 59.98 cM, cytoband E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92508
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAmino acids 283-295, coded by exon 6, were replaced with an IRES-lacZ and neo cassette. Correct targeting was confirmed by Southern blot analysis. Quantitative PCR of heterozygotes showed a mean reduction of 40% in mRNA levels in the duodenum, ileum, and colon relative to wild-type mice. (J:92508)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr5a2 Mutation:  81 strains or lines available
References
Original:  J:92508 Botrugno OA, et al., Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation. Mol Cell. 2004 Aug 27;15(4):499-509
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory