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Targeted Allele Detail
Symbol: Col19a1tm1Rmz
Name: collagen, type XIX, alpha 1; targeted mutation 1, Francesco Ramirez
MGI ID: MGI:3053870
Synonyms: N19
Gene: Col19a1  Location: Chr1:24261890-24587472 bp, - strand  Genetic Position: Chr1, 9.99 cM, cytoband A3
Germline Transmission:  Earliest citation of germline transmission: J:92510
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neo cassette replaced exon 4, which codes for 32 internal amino acids of the 268-residue NC6 peptide and includes split codons for the first and last residues. Northern blot demonstrated lack of mRNA transcripts in homozygotes. Sequencing of RT-PCR products showed that there were no shorter in-frame transcripts present. Immunoblots demonstrated the absence of the expected 165-kD collagenase-sensitive product. (J:92510)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Col19a1 Mutation:  56 strains or lines available
Original:  J:92510 Sumiyoshi H, et al., Esophageal muscle physiology and morphogenesis require assembly of a collagen XIX-rich basement membrane zone. J Cell Biol. 2004 Aug 16;166(4):591-600
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory