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Lamp1tm1Psa
Targeted Allele Detail
Nomenclature
Symbol: Lamp1tm1Psa
Name: lysosomal-associated membrane protein 1; targeted mutation 1, Paul Saftig
MGI ID: MGI:3053864
Synonyms: Cd107a-, LAMP-1 -
Gene: Lamp1  Location: Chr8:13159135-13175338 bp, + strand  Genetic Position: Chr8, 5.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54567
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin gene was inserted in exon 3 which created a premature stop codon in the open reading frame. Absence of gene transcript was indicated by Northern blot analysis and western blot analysis confirmed the absence of protein product. (J:54567)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamp1 Mutation:  4 strains or lines available
References
Original:  J:54567 Andrejewski N, et al., Normal lysosomal morphology and function in LAMP-1-deficient mice. J Biol Chem. 1999 Apr 30;274(18):12692-701
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory