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Kcnma1tm1Rwa
Targeted Allele Detail
Summary
Symbol: Kcnma1tm1Rwa
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1; targeted mutation 1, Richard W Aldrich
MGI ID: MGI:3053849
Synonyms: KCa1.1-, Slo-
Gene: Kcnma1  Location: Chr14:23342356-24055173 bp, - strand  Genetic Position: Chr14, 12.92 cM
Alliance: Kcnma1tm1Rwa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92539
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted to flank exon 1. In addition, EGFP-FRT-flanked neomycin cassette was inserted 3' to exon 1. The floxed exon was removed by mating mutant animals to the cre deleter strain FVB/N-Tg(EIIa-cre)C5379Lmgd/J. Protein was undetectable by Western blot analysis of bladder proteins. The EGFP-neomycin cassette was not removed by Cre recombinase. (J:92539)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnma1 Mutation:  101 strains or lines available
References
Original:  J:92539 Meredith AL, et al., Overactive bladder and incontinence in the absence of the BK large conductance Ca2+-activated K+ channel. J Biol Chem. 2004 Aug 27;279(35):36746-52
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory