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Tg(TNF)197Gkl
Transgene Detail
Nomenclature
Symbol: Tg(TNF)197Gkl
Name: transgene insertion 197, George Kollias
MGI ID: MGI:3053711
Synonyms: hTNFtg, Tg197, Tg197 hTNFtg
Transgene: Tg(TNF)197Gkl  Location: unknown  
Transgene
origin
Strain of Origin:  (CBA x C57BL/6)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TNF)197Gkl expresses 1 gene
 
Mutation detailsThe transgene comprises the human tumor necrosis factor gene with its 3' UTR, polyadenylation signal and flanking sequence replaced by those of the human hemoglobin beta (HBB) gene. This modification interferes with posttranscriptional regulation of TNF expression, altering expression levels and timing, but apparently not its tissue specificity. Line 197 carries approximately 5 tandemly-arrayed copies of the transgene. (J:92576)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:92576 Keffer J, et al., Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J. 1991 Dec;10(13):4025-31
All:  39 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory