Tg(Eno2tTA)5021Nes
Transgene Detail

Summary

• Symbol: Tg(Eno2tTA)5021Nes
• Name: transgene insertion 5021, Eric Nestler
• MGI ID: MGI:3053186
• Synonyms: line B, NSE-tTA
• Transgene: Tg(Eno2tTA)5021Nes Location: unknown
• Alliance: Tg(Eno2tTA)5021Nes page

Transgene origin

• Strain of Origin: (SJL x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: This transgene consists of a 1.8kb fragment of the rat Eno2 promoter, an SV40 intron, a poly A signal sequence, and a modified tetracycline transactivator cDNA. (J:92225)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

B6.Cg-TgN(Eno2tTA)5021Nes mice selectively express tTA at high levels in the striatum and cerebellum. When these transgenic mice are mated to a second transgenic strain which carries a gene of interest under the regulation of a tetracycline-responsive promoter element (TRE), expression of the target gene in the bitransgenic offspring may be induced in those tissues where tTA is expressed by the withdrawal of the tetracycline analog, doxycycline (dox).

References

• Original: J:92225 Chen J, et al., Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol. 1998 Sep;54(3):495-503
• All: 11 reference(s)