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Targeted Allele Detail
Symbol: Tnfrsf1atm1.1Gkl
Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 1.1, George Kollias
MGI ID: MGI:3053140
Synonyms: P55deltaNS
Gene: Tnfrsf1a  Location: Chr6:125349723-125362483 bp, + strand  Genetic Position: Chr6, 59.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:92470
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA targeting vector was designed to delete 15 nucleotides in exon 6 encoding amino acids 202-206. Southern blot and PCR confirmed recombination. Flow cytometry of peritoneal cells indicated that the mutation abolished receptor shedding. Cre-mediated recombination removed the floxed selection cassette. (J:92470)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf1a Mutation:  26 strains or lines available
Original:  J:92470 Xanthoulea S, et al., Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med. 2004 Aug 2;200(3):367-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory