Tg(tetO-Jun)5Nes
Transgene Detail
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Symbol: |
Tg(tetO-Jun)5Nes |
Name: |
transgene insertion 5, Eric Nestler |
MGI ID: |
MGI:3053118 |
Synonyms: |
E line, TetOp-FLAG-deltac-Jun, TetOp-FLAG-deltacJun line E |
Transgene: |
Tg(tetO-Jun)5Nes Location: unknown
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Alliance: |
Tg(tetO-Jun)5Nes page
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Transgene Type: |
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Transgenic (Dominant negative, Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Mutation details: A truncated dominant negative form of the Jun transcription factor is expressed by this transgene. Transcription is directed by a tetracycline-responsive promoter element (TRE). When bred with another transgenic mouse expressing tetracycline-controlled transactivator protein (tTA) to create a bitransgenic animal, Fosb expression can be negatively regulated with the tetracycline analog, doxycycline.
(J:83308)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:83308 Peakman MC, et al., Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine. Brain Res. 2003 Apr 25;970(1-2):73-86 |
All: |
5 reference(s) |
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