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Viptm1Clw
Targeted Allele Detail
Nomenclature
Symbol: Viptm1Clw
Name: vasoactive intestinal polypeptide; targeted mutation 1, Christopher S Colwell
MGI ID: MGI:3053090
Synonyms: VIP-, VIP KO, VIP/PHI-
Gene: Vip  Location: Chr10:5639218-5647617 bp, + strand  Genetic Position: Chr10, 1.97 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:86544
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance gene was inserted in reverse orientation into exon 4. PCR confirmed recombination in mutant mice. Immunohistochemistry confirmed the loss of protein in homozygotes. (J:86544)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vip Mutation:  13 strains or lines available
References
Original:  J:86544 Colwell CS, et al., Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R939-49
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory