Gp2^tm1Soka
Targeted Allele Detail

Summary

• Symbol: Gp2^tm1Soka
• Name: glycoprotein 2 zymogen granule membrane; targeted mutation 1, S Fukuoka
• MGI ID: MGI:3052837
• Synonyms: Gp2^-
• Gene: Gp2 Location: Chr7:119041760-119058495 bp, - strand Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
• Alliance: Gp2^tm1Soka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92161
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to replace part of exon 3 and exon 4 with a PGK-beta-geo selection cassette. Southern blotting identified correctly targeted cells. RT-PCR showed that expression was completely abolished. (J:92161)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gp2 Mutation: 42 strains or lines available

References

• Original: J:92161 Kobayashi K, et al., GP2/THP gene family of self-binding, GPI-anchored proteins forms a cluster at chromosome 7F1 region in mouse genome. Biochem Biophys Res Commun. 2004 Sep 17;322(2):659-64
• All: 1 reference(s)