Ptger4^tm1Matb
Targeted Allele Detail

Summary

• Symbol: Ptger4^tm1Matb
• Name: prostaglandin E receptor 4 (subtype EP4); targeted mutation 1, Matthew D Breyer
• MGI ID: MGI:3052800
• Synonyms: EP4^lox+neo
• Gene: Ptger4 Location: Chr15:5262880-5273668 bp, - strand Genetic Position: Chr15, 1.99 cM
• Alliance: Ptger4^tm1Matb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92301
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette and a LoxP site were inserted flanking exon 2, which encodes slightly more than five of the seven transmembrane-spanning domains. RT-PCR revealed decreased mRNA expression from the mutant allele. (J:92301)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger4 Mutation: 31 strains or lines available

References

• Original: J:92301 Schneider A, et al., Generation of a conditional allele of the mouse prostaglandin EP(4) receptor. Genesis. 2004 Sep;40(1):7-14
• All: 2 reference(s)