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Prnptm1Tuzi
Targeted Allele Detail
Nomenclature
Symbol: Prnptm1Tuzi
Name: prion protein; targeted mutation 1, Nadia L Tuzi
MGI ID: MGI:3052798
Synonyms: Prpstop
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92302
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed Betageo cassette was inserted into intron 2. PCR confirmed recombination in mice. Northern blot demonstrated that transcription was abolished and Western blot indicated a complete absence of protein in mutant brains. (J:92302)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  84 strains or lines available
References
Original:  J:92302 Tuzi NL, et al., Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases. Genesis. 2004 Sep;40(1):1-6
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory