Pex7^tm1Rjaw
Targeted Allele Detail

Summary

• Symbol: Pex7^tm1Rjaw
• Name: peroxisomal biogenesis factor 7; targeted mutation 1, Ronald JA Wanders
• MGI ID: MGI:3052739
• Synonyms: Pex7-
• Gene: Pex7 Location: Chr10:19735836-19783420 bp, - strand Genetic Position: Chr10, 9.16 cM, cytoband A3
• Alliance: Pex7^tm1Rjaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92346
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta galactosidase reporter gene fused with a neomycin phosphotransferas gene (beta geo cassette) replaced exon 3 and parts of introns 2 and 3 of the gene. (J:92346)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pex7 Mutation: 17 strains or lines available

References

• Original: J:92346 Brites P, et al., Impaired neuronal migration and endochondral ossification in Pex7 knockout mice: a model for rhizomelic chondrodysplasia punctata. Hum Mol Genet. 2003 Sep 15;12(18):2255-67
• All: 5 reference(s)