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Mtortm1Yam
Targeted Allele Detail
Nomenclature
Symbol: Mtortm1Yam
Name: mechanistic target of rapamycin kinase; targeted mutation 1, Shinya Yamanaka
MGI ID: MGI:3052669
Synonyms: mTOR-
Gene: Mtor  Location: Chr4:148448611-148557683 bp, + strand  Genetic Position: Chr4, 78.76 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92252
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 44 to 47, encoding the kinase domain, were replaced by an IRES-Betageo-pA cassette. Northern blot of heterozygous ES cells showed reduced expression and detected a larger transcript, corresponding to the fusion of Frap1 to Betageo. Western blot showed that protein levels were also reduced. (J:92252)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mtor Mutation:  11 strains or lines available
References
Original:  J:92252 Murakami M, et al., mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol Cell Biol. 2004 Aug;24(15):6710-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory