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Tg(Ins2-TAg)1Lt
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-TAg)1Lt
Name: transgene insertion 1, Edward H Leiter
MGI ID: MGI:3052662
Synonyms: Tg(RipTAg)1Lt
Transgene: Tg(Ins2-TAg)1Lt  Location: unknown  
Transgene
origin
Strain of Origin:  NOD/ShiLt
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgene contains rat insulin 2 promoter (Rip) and the wild-type allele of the SV40 large T antigen (TAg) gene. (J:92449)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
Homozygous transgenic mice on an NOD/Lt genetic background develop pancreatic beta cell adenomas. They are able to produce 2-3 litters before the insulin secreted from the adenoma makes them too hypoglycemic.
References
Original:  J:92449 Hamaguchi K, et al., NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes. 1991 Jul;40(7):842-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory