Tg(Ins2-TAg)1Lt
Transgene Detail
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| Symbol: |
Tg(Ins2-TAg)1Lt |
| Name: |
transgene insertion 1, Edward H Leiter |
| MGI ID: |
MGI:3052662 |
| Synonyms: |
Tg(RipTAg)1Lt |
| Transgene: |
Tg(Ins2-TAg)1Lt Location: unknown
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgene contains rat insulin 2 promoter (Rip) and the wild-type allele of the SV40 large T antigen (TAg) gene.
(J:92449)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 2 strains available
Cell Lines: 0 lines available
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Homozygous transgenic mice on an NOD/Lt genetic background develop pancreatic beta cell adenomas. They are able to produce 2-3 litters before the insulin secreted from the adenoma makes them too hypoglycemic.
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| Original: |
J:92449 Hamaguchi K, et al., NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes. 1991 Jul;40(7):842-9 |
| All: |
6 reference(s) |
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Analysis Tools
