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Tg(Neurog3-cre)C1Able
Transgene Detail
Nomenclature
Symbol: Tg(Neurog3-cre)C1Able
Name: transgene insertion C1, Andrew B Leiter
MGI ID: MGI:3052639
Synonyms: Neurgo3TgBAC-Cre, Neurog3(cre), Neurog3Cre, ngn3-Cre, Tg(Neurog3-cre)#Able
Transgene: Tg(Neurog3-cre)C1Able  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThe Cre recombinase coding sequence, flanked by a nuclear localization signal and an SV40 polyadenylation site, was inserted just after the translation start site of the neurogenin 3 gene present in mouse BAC RP23-121F10, which also includes approximately 81 kb of 5' and 102 kb of 3' flanking DNA. Immunohistochemical analysis shows the same expression pattern for cre as for neurogenin 3 in adult and embryonic mice bearing this transgene. Cre recombinase activity is seen in cell types of pancreas, stomach, small intestine and colon that express or are descended from cells that express neurogenin 3 during development. (J:92204)
Recombinase
activity
Activity:
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Driver: Neurog3     Summary of all recombinase alleles driven by Neurog3. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Notes
This is one of two independent lines demonstrating identical expression patterns.
References
Original:  J:92204 Schonhoff SE, et al., Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Dev Biol. 2004 Jun 15;270(2):443-54
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory