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Tg(H2-Ead)12Lt
Transgene Detail
Nomenclature
Symbol: Tg(H2-Ead)12Lt
Name: transgene insertion 12, Edward H Leiter
MGI ID: MGI:3052550
Synonyms: Tg(I-Ealphad,line 12)3Lt
Transgene: Tg(H2-Ead)12Lt  Location: unknown  
Transgene
origin
Strain of Origin:  NOD/ShiLt
Transgene
description
Transgene Type:    Transgenic (random, expressed)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Diabetes incidence in transgenic mice carrying line 12 is greatly reduced (25% of females, 0% of males) where H2-Ea expression on antigen presenting cells is comparable to BALB/cByJ controls. Although the presence of the transgene in both lines 5 and 12 confers protective influence from IDDM pathologies that affect pancreatic beta cells, autoimmune pathologies effecting other tissues (submandibular salivary, thyroid, kidney) are observed. Histologic examination of the pancreas reveals perivascular/periductal infiltration and peri-insulitus.

References
Original:  J:36435 Hanson MS, et al., Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunol. 1996 Aug 1;157(3):1279-87
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory