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Transgene Detail
Symbol: Tg(H2-Ead)12Lt
Name: transgene insertion 12, Edward H Leiter
MGI ID: MGI:3052550
Synonyms: Tg(I-Ealphad,line 12)3Lt
Transgene: Tg(H2-Ead)12Lt  Location: unknown  
Strain of Origin:  NOD/ShiLt
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(H2-Ead)12Lt expresses 1 gene
Mutation detailsThe construct contains a complete H2-Ead gene from the BALB/cByJ mouse including flanking sequence. One copy of the transgene integrated into the genome of line 12 whereas four copies are present in line 5. (J:36435)
View phenotypes for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Diabetes incidence in transgenic mice carrying line 12 is greatly reduced (25% of females, 0% of males) where H2-Ea expression on antigen presenting cells is comparable to BALB/cByJ controls. Although the presence of the transgene in both lines 5 and 12 confers protective influence from IDDM pathologies that affect pancreatic beta cells, autoimmune pathologies effecting other tissues (submandibular salivary, thyroid, kidney) are observed. Histologic examination of the pancreas reveals perivascular/periductal infiltration and peri-insulitus.

Original:  J:36435 Hanson MS, et al., Quantitative thresholds of MHC class II I-E expressed on hemopoietically derived antigen-presenting cells in transgenic NOD/Lt mice determine level of diabetes resistance and indicate mechanism of protection. J Immunol. 1996 Aug 1;157(3):1279-87
All:  1 reference(s)

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