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Ezrtm1Aim
Targeted Allele Detail
Nomenclature
Symbol: Ezrtm1Aim
Name: ezrin; targeted mutation 1, Andrea I McClatchey
MGI ID: MGI:3052158
Synonyms: Ez-, Ezdelta345-Betageo
Gene: Ezr  Location: Chr17:6738131-6782780 bp, - strand  Genetic Position: Chr17, 4.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92210
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted to flank exons 3-5. An FRT-flanked promoterless Beta-galactosidase-neomycin cassette was inserted into intron 5. Crossing to EIIa-Cre mice excised the floxed region containing exons 3-5 and left the FRT-flanked Beta-geo. Immunohistochemical analysis of mutants confirmed absence of endogenous protein. Western blot of mutant neonate intenstinal tissue also demonstrated absence of protein. (J:92210)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ezr Mutation:  59 strains or lines available
References
Original:  J:92210 Saotome I, et al., Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell. 2004 Jun;6(6):855-64
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory