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Targeted Allele Detail
Symbol: Zic5tm1Jaru
Name: zinc finger protein of the cerebellum 5; targeted mutation 1, Jun Aruga
MGI ID: MGI:3052154
Synonyms: Deltaneo
Gene: Zic5  Location: Chr14:122459160-122465658 bp, - strand  Genetic Position: Chr14, 65.96 cM, cytoband E5
Germline Transmission:  Earliest citation of germline transmission: J:92220
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to delete 2.3 kb of exon one containing the ATG and encoding three of the five zinc finger motifs. A floxed neo replaced the sequence and was subsequently excised by crossing with mice expressing Cre in the germ line. Immunohistochemistry of mutant hindbrain samples showed no significant immunoreactivity. (J:92220)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zic5 Mutation:  7 strains or lines available
Original:  J:92220 Inoue T, et al., Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol. 2004 Jun 1;270(1):146-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
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