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Crb1tm1Wij
Targeted Allele Detail
Nomenclature
Symbol: Crb1tm1Wij
Name: crumbs family member 1, photoreceptor morphogenesis associated; targeted mutation, Jan Wijnholds
MGI ID: MGI:3052072
Synonyms: Crb1-
Gene: Crb1  Location: Chr1:139197056-139377100 bp, - strand  Genetic Position: Chr1, 60.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92068
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA hygromycin resistance cassette replaced 2.9 kb of the upstream promoter region, exon 1 and part of intron 1. Southern blot confirmed a smaller product size and immunoprecipitation indicated no detectable protein. (J:92068)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crb1 Mutation:  16 strains or lines available
References
Original:  J:92068 Van De Pavert SA, et al., Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. J Cell Sci. 2004 Aug 15;117(Pt 18):4169-77
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory