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Transgene Detail
Symbol: Tg(Eno2tTA)5030Nes
Name: transgene insertion 5030, Eric Nestler
MGI ID: MGI:3051985
Synonyms: A line, NSE-tTA, Tg(Eno2-tTA)ANes
Transgene: Tg(Eno2tTA)5030Nes  Location: unknown  
Strain of Origin:  (SJL x C57BL/6)F1
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
Mutation detailsThis transgene consists of a 1.8kb fragment of the rat Eno2 promoter, an SV40 intron, a poly A signal sequence, and a modified tetracycline transactivator cDNA. (J:92225)
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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
B6.Cg-TgN(Eno2tTA)5030Nes mice selectively express tTA at high levels in the striatum and to a lesser extent in the cerebral cortex and hippocampus. When these transgenic mice are mated to a second transgenic strain which carries a gene of interest under the regulation of a tetracycline-responsive promoter element (TRE), expression of the target gene in the bitransgenic offspring may be induced in those tissues where tTA is expressed by the withdrawal of the tetracycline analog, doxycycline (dox).
Original:  J:92225 Chen J, et al., Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol. 1998 Sep;54(3):495-503
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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