About   Help   FAQ
Tg(Eno2tTA)5030Nes
Transgene Detail
Nomenclature
Symbol: Tg(Eno2tTA)5030Nes
Name: transgene insertion 5030, Eric Nestler
MGI ID: MGI:3051985
Synonyms: A line, NSE-tTA, Tg(Eno2-tTA)ANes
Transgene: Tg(Eno2tTA)5030Nes  Location: unknown  
Transgene
origin
Strain of Origin:  (SJL x C57BL/6)F1
Transgene
description
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of a 1.8kb fragment of the rat Eno2 promoter, an SV40 intron, a poly A signal sequence, and a modified tetracycline transactivator cDNA. (J:92225)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
B6.Cg-TgN(Eno2tTA)5030Nes mice selectively express tTA at high levels in the striatum and to a lesser extent in the cerebral cortex and hippocampus. When these transgenic mice are mated to a second transgenic strain which carries a gene of interest under the regulation of a tetracycline-responsive promoter element (TRE), expression of the target gene in the bitransgenic offspring may be induced in those tissues where tTA is expressed by the withdrawal of the tetracycline analog, doxycycline (dox).
References
Original:  J:92225 Chen J, et al., Transgenic animals with inducible, targeted gene expression in brain. Mol Pharmacol. 1998 Sep;54(3):495-503
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/16/2021
MGI 6.17
The Jackson Laboratory