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Ubash3atm1Jni
Targeted Allele Detail
Nomenclature
Symbol: Ubash3atm1Jni
Name: ubiquitin associated and SH3 domain containing, A; targeted mutation 1, James N Ihle
MGI ID: MGI:3051962
Synonyms: Sts2-
Gene: Ubash3a  Location: Chr17:31207873-31242202 bp, + strand  Genetic Position: Chr17, 15.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89761
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn 11 kb fragment of sequence containing exons 6, 7 and part of 8 was replaced with a neomycin resistance gene. Southern blot confirmed correct targeting and Northern blot demonstrated an absence of mRNA in homozygotes. Western blot indicated absence of protein in mutants. (J:89761)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ubash3a Mutation:  20 strains or lines available
References
Original:  J:89761 Carpino N, et al., Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Immunity. 2004 Jan;20(1):37-46
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory