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Atp2b1tm1Ges
Targeted Allele Detail
Nomenclature
Symbol: Atp2b1tm1Ges
Name: ATPase, Ca++ transporting, plasma membrane 1; targeted mutation 1, Gary E Shull
MGI ID: MGI:3051541
Synonyms: Pmca1-
Gene: Atp2b1  Location: Chr10:98915152-99026143 bp, + strand  Genetic Position: Chr10, 50.97 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91844
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCodons 466-529 in exon 10, including the catalytic phosphorylation site (aspartic acid 475), were replaced with a neomycin resistance gene. Northern blot indicated no difference in levels of mRNA between wild-type and heterozygous mice. RT-PCR confirmed that the exon 9 was spliced to exon 11, producing the transcript of the expected length. (J:91844)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atp2b1 Mutation:  35 strains or lines available
References
Original:  J:91844 Okunade GW, et al., Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4. J Biol Chem. 2004 Aug 6;279(32):33742-50
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory