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Socs3tm1Ayos
Targeted Allele Detail
Summary
Symbol: Socs3tm1Ayos
Name: suppressor of cytokine signaling 3; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:3051525
Synonyms: Socs3fl, Socs3flox
Gene: Socs3  Location: Chr11:117856905-117860192 bp, - strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Alliance: Socs3tm1Ayos page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92040
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted in intron 1 and in the 3' UTR of exon 2, thereby surrounding the coding sequence. Southern blot confirmed recombination. (J:92040)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Socs3 Mutation:  16 strains or lines available
References
Original:  J:92040 Yasukawa H, et al., IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol. 2003 Jun;4(6):551-6
All:  75 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory