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Tg(TcraTcrb)8Rest
Transgene Detail
Nomenclature
Symbol: Tg(TcraTcrb)8Rest
Name: transgene insertion 8, Nicholas Restifo
MGI ID: MGI:3051150
Synonyms: Pmel-1, pmel-17, Pmel-I
Transgene: Tg(TcraTcrb)8Rest  Location: unknown  Genetic Position: Chr2, Syntenic
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TcraTcrb)8Rest expresses 2 genes
 
Mutation detailsThese coinjected transgenes encode an H2-Db-restricted Valpha1 Vbeta13 T-cell receptor that recognizes a peptide comprising amino acids 25-33 of the protein known as pmel-17/gp100, a pigment biosynthetic enzyme that is encoded by the mouse Si (silver) gene and is expressed both in normal melanocytes and in malignant melanoma. The insertion is accompanied by a 157-bp deletion (chr2: 68,208,872?68,209,029 bp - build unknown). (J:85058, J:208902)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:85058 Overwijk WW, et al., Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells. J Exp Med. 2003 Aug 18;198(4):569-80
All:  130 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory