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Targeted Allele Detail
Symbol: Cd274tm2Shr
Name: CD274 antigen; targeted mutation 2, Arlene H Sharpe
MGI ID: MGI:3050804
Synonyms: PD-L1-
Gene: Cd274  Location: Chr19:29367455-29388095 bp, + strand  Genetic Position: Chr19, 23.88 cM, cytoband C2
Germline Transmission:  Earliest citation of germline transmission: J:91480
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced the signal exon and two-thirds of the IgV exon. Southern blot confirmed recombination. (J:91480)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd274 Mutation:  49 strains or lines available
Original:  J:91480 Latchman YE, et al., PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10691-6
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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