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Cd274tm1Shr
Targeted Allele Detail
Nomenclature
Symbol: Cd274tm1Shr
Name: CD274 antigen; targeted mutation 1, Arlene H Sharpe
MGI ID: MGI:3050803
Synonyms: PD-L1-
Gene: Cd274  Location: Chr19:29367455-29388095 bp, + strand  Genetic Position: Chr19, 23.88 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91480
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe signal and all of the IgV exon was replaced with a neomycin resistance gene. Southern blot confirmed recombination. Flow cytometry showed lack of expression in B cells, T cells, macrophages or DCs in mutants. (J:91480)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cd274 Mutation:  22 strains or lines available
References
Original:  J:91480 Latchman YE, et al., PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10691-6
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory