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Targeted Allele Detail
Symbol: Hrh3tm1Kot
Name: histamine receptor H3; targeted mutation 1, Hidehito Kotani
MGI ID: MGI:3050799
Synonyms: H3-
Gene: Hrh3  Location: Chr2:180099465-180104488 bp, - strand  Genetic Position: Chr2, 102.62 cM
Germline Transmission:  Earliest citation of germline transmission: J:80824
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 994 bp segment including exon 1 was replaced with a neo cassette via homologous recombination. Northern blot analysis confirmed the absence of mRNA expression from this allele. (J:80824)
Inheritance:    Not Specified
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hrh3 Mutation:  8 strains or lines available
Original:  J:80824 Takahashi K, et al., Targeted disruption of H3 receptors results in changes in brain histamine tone leading to an obese phenotype. J Clin Invest. 2002 Dec;110(12):1791-9
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.07
The Jackson Laboratory