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Socs5tm1Wsa
Targeted Allele Detail
Nomenclature
Symbol: Socs5tm1Wsa
Name: suppressor of cytokine signaling 5; targeted mutation 1, Warren S Alexander
MGI ID: MGI:3050577
Synonyms: Socs5-
Gene: Socs5  Location: Chr17:87107679-87137839 bp, + strand  Genetic Position: Chr17, 56.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91591
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe single coding exon was replaced with an unexpected duplication of the targeting vector containing one lacZ-floxed neo cassette such that two cassettes were inserted. Northern blotting and reverse transcription-PCR revealed absence of transcripts in all tissues examined. (J:91591)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Socs5 Mutation:  11 strains or lines available
References
Original:  J:91591 Brender C, et al., SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function. Mol Cell Biol. 2004 Jul;24(13):6094-103
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory