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Kcnk4tm1Lzd
Targeted Allele Detail
Nomenclature
Symbol: Kcnk4tm1Lzd
Name: potassium channel, subfamily K, member 4; targeted mutation 1, Michel Lazdunski
MGI ID: MGI:3050222
Synonyms: TRAAK-
Gene: Kcnk4  Location: Chr19:6925710-6934515 bp, - strand  Genetic Position: Chr19, 5.08 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91531
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details100 bp of exon 2, encoding most of the first transmembrane domain, was replaced by an IRES-geo-neo cassette. The insertion was 54 bp after the start codon of the endogenous coding sequence, and the presence of stop codons in three reading frames upstream of the IRES-geo-neo allowed interruption of translation of the endogenous mRNA 18 amino acids after the beginning. Southern blot confirmed recombination and Western blot indicated lack of wild-type protein in mutant brains. (J:91531)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnk4 Mutation:  9 strains or lines available
References
Original:  J:91531 Heurteaux C, et al., TREK-1, a K(+) channel involved in neuroprotection and general anesthesia. EMBO J. 2004 Jul 7;23(13):2684-95
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory