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Targeted Allele Detail
Symbol: Kcnma1tm1Ruth
Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1; targeted mutation 1, P Ruth
MGI ID: MGI:3050114
Synonyms: BK-, BKalpha-, BK-KO, BK L1
Gene: Kcnma1  Location: Chr14:23299381-24004859 bp, - strand  Genetic Position: Chr14, 12.92 cM
Germline Transmission:  Earliest citation of germline transmission: J:91427
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA single loxp site was inserted upstream of the exon encoding the pore-forming alpha subunit, and a floxed neo-TK cassette downstream. Transient cre-expression excised the floxed region including the exon and neo-TK. Southern blot and PCR confirmed recombination and Western blot of brain membrane proteins from mutants indicated absence of the C-terminus of the alpha subunit. (J:91427)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnma1 Mutation:  47 strains or lines available
Original:  J:91427 Sausbier M, et al., Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9474-8
All:  24 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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