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Ppargtm1Mae
Targeted Allele Detail
Nomenclature
Symbol: Ppargtm1Mae
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, Nobuyo Maeda
MGI ID: MGI:3050095
Synonyms: PPARgammaL, PPAR-gammaP465L, PpargP465L
Gene: Pparg  Location: Chr6:115360951-115490399 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91362
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Dominant negative, Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsA missense mutation was introduced to replace proline at position 465 in exon 6 with leucine (P465L). An ACN cassette containing a testis-specific Ace promoter, Cre recombinase and Neo-resistance gene was excised upon germline transmission. Southern blot confirmed recombination. (J:91362)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  29 strains or lines available
References
Original:  J:91362 Tsai YS, et al., Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest. 2004 Jul;114(2):240-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory