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Klf2tm1Ling
Targeted Allele Detail
Nomenclature
Symbol: Klf2tm1Ling
Name: Kruppel-like factor 2 (lung); targeted mutation 1, Jerry B Lingrel
MGI ID: MGI:3047647
Synonyms: LKLF-
Gene: Klf2  Location: Chr8:72319033-72321656 bp, + strand  Genetic Position: Chr8, 34.99 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51402
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn expression cassette of the hypoxanthine phosphoriboyltrasferase (HPRT) gene replaced the promoter region, and sequences encoding the transcription activation domain and part of the DNA binding domain of the gene. Northern and RT-PCR analysis showed that a null allele was obtained. (J:51402)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 25 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klf2 Mutation:  6 strains or lines available
References
Original:  J:51402 Wani MA, et al., Loss of LKLF function results in embryonic lethality in mice. Transgenic Res. 1998 Jul;7(4):229-38
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory