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Tg(Cr2-cre)3Cgn
Transgene Detail
Nomenclature
Symbol: Tg(Cr2-cre)3Cgn
Name: transgene insertion 3, University of Cologne
MGI ID: MGI:3047571
Synonyms: CD21-cre, CD21-cre3a, Cr2tm1(cre)Cgn
Transgene: Tg(Cr2-cre)3Cgn  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of a cre expression cassette including a Kozak sequence, nuclear localization signal, and bovine growth hormone polyadenylation signal inserted into a BAC containing the Cr2 locus. The ATG in the first exon of Cr2 is also mutated in this allele. Cre mediated recombination is detected in 60% - 80% of mature B cells and is undetectable in pro/pre-B and immature B cells. (J:91091)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cr2     Summary of all recombinase alleles driven by Cr2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:91091 Kraus M, et al., Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell. 2004 Jun 11;117(6):787-800
All:  53 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory