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Prndtm1Aag
Targeted Allele Detail
Summary
Symbol: Prndtm1Aag
Name: prion like protein doppel; targeted mutation 1, Adriano Aguzzi
MGI ID: MGI:3047561
Synonyms: Prndneo
Gene: Prnd  Location: Chr2:131792781-131798050 bp, + strand  Genetic Position: Chr2, 64.07 cM
Alliance: Prndtm1Aag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91621
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire open reading frame was replaced with a floxed neo cassette via homologous recombination. RT-PCR and western blot analysis confirmed the absence of RNA and protein expression in homozygous mutants. (J:91621, J:91622)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prnd Mutation:  6 strains or lines available
References
Original:  J:91621 Behrens A, et al., Absence of the prion protein homologue Doppel causes male sterility. EMBO J. 2002 Jul 15;21(14):3652-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory