Cd79a^tm4Cgn
Targeted Allele Detail

Summary

• Symbol: Cd79a^tm4Cgn
• Name: CD79A antigen (immunoglobulin-associated alpha); targeted mutation 4, University of Cologne
• MGI ID: MGI:3047536
• Synonyms: Igalpha^Tmf
• Gene: Cd79a Location: Chr7:24596922-24601283 bp, + strand Genetic Position: Chr7, 13.49 cM
• Alliance: Cd79a^tm4Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91091
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted upstream of exons 2 and 4, surrounding the extracellular membrane and transmemebrane encoding sequences. Transient cre expression excised a floxed neo upstream of exon 2. Southern blot confirmed recombination and excision of the neo. Flow cytometry of bone marrow, blood, peritoneal and splenic B cells in homozygous mice indicated gene expression levels were normal. (J:91091)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd79a Mutation: 22 strains or lines available

References

• Original: J:91091 Kraus M, et al., Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer. Cell. 2004 Jun 11;117(6):787-800
• All: 1 reference(s)