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Prnp/Prndtm1Dwm
Targeted Allele Detail
Nomenclature
Symbol: Prnp/Prndtm1Dwm
Name: prion protein; targeted mutation 1, David W Melton
MGI ID: MGI:3047062
Synonyms: Prnp-/Prnd-
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91094
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsBoth coding regions were ablated by replacement with an Hprt minigene. Western blot of mutant testes lysates show absence of both proteins. (J:91094)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  89 strains or lines available
References
Original:  J:91094 Paisley D, et al., Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am J Pathol. 2004 Jun;164(6):2279-88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory