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Nfkbiztm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Nfkbiztm1Aki
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3046930
Synonyms: IkappaBzeta-
Gene: Nfkbiz  Location: Chr16:55811375-55838899 bp, - strand  Genetic Position: Chr16, 33.65 cM, cytoband C1.2 - C1.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91297
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequence encoding the central portion of the gene was replaced with a neo cassette. Northern blot indicated absence of transcript and Western blot showed no protein present in mutants. (J:91297)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkbiz Mutation:  11 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Stevens-Johnson Syndrome (J:96363 and J:141704)
References
Original:  J:91297 Yamamoto M, et al., Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta. Nature. 2004 Jul 8;430(6996):218-22
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory