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Fxr1tm1.2Dln
Targeted Allele Detail
Nomenclature
Symbol: Fxr1tm1.2Dln
Name: fragile X mental retardation gene 1, autosomal homolog; targeted mutation 1.2, David L Nelson
MGI ID: MGI:3046849
Gene: Fxr1  Location: Chr3:34019943-34070322 bp, + strand  Genetic Position: Chr3, 16.41 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91191
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsFxr1htm1.1Dln mice were crossed with CAG-Cre expressing mice, resulting in an allele with a single loxp site in the place of the promoter and exon 1. Western blot analysis indicated lack of protein in mutant heart, muscle, and brain. (J:91191)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fxr1 Mutation:  159 strains or lines available
References
Original:  J:91191 Mientjes EJ, et al., Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo. Hum Mol Genet. 2004 Jul 1;13(13):1291-302
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory