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Targeted Allele Detail
Symbol: Otx2tm5Sia
Name: orthodenticle homolog 2; targeted mutation 5, Shinichi Aizawa
MGI ID: MGI:3046839
Synonyms: Otx2deltaFM
Gene: Otx2  Location: Chr14:48657679-48667644 bp, - strand  Genetic Position: Chr14, 25.36 cM
Germline Transmission:  Earliest citation of germline transmission: J:91011
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe FM enhancer region (1.4 kb) was replaced with a floxed neomycin-resistance gene. Southern blot and PCR confirmed recombination. Gene expression was shown to be diminished. (J:91011)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  37 strains or lines available
Original:  J:91011 Kurokawa D, et al., Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development. 2004 Jul;131(14):3319-31
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory