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Tbx1tm2Bld
Targeted Allele Detail
Nomenclature
Symbol: Tbx1tm2Bld
Name: T-box 1; targeted mutation 2, Antonio Baldini
MGI ID: MGI:3046792
Synonyms: Tbx1neo
Gene: Tbx1  Location: Chr16:18581704-18590671 bp, - strand  Genetic Position: Chr16, 11.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91013
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation detailsA floxed PGK-neo cassette and a third loxP site were inserted such that cre mediated recombination may excise exon 5 and/or the neo cassette. RT-PCR indicates that this is a hypomorphic allele. (J:91013)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx1 Mutation:  19 strains or lines available
References
Original:  J:91013 Xu H, et al., Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development. 2004 Jul;131(13):3217-27
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory