Tbk1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tbk1^tm1Aki
• Name: TANK-binding kinase 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3046789
• Synonyms: Tbk1^-
• Gene: Tbk1 Location: Chr10:121382360-121422692 bp, - strand Genetic Position: Chr10, 69.84 cM
• Alliance: Tbk1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91363
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 9 was replaced with a neomycin resistance gene. Northern blot indicated the absence of protein in mutant MEFs. (J:91363)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbk1 Mutation: 54 strains or lines available

References

• Original: J:91363 Hemmi H, et al., The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50
• All: 31 reference(s)