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Ikbketm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Ikbketm1Aki
Name: inhibitor of kappaB kinase epsilon; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3046788
Synonyms: Ikk-I-
Gene: Ikbke  Location: Chr1:131254343-131279606 bp, - strand  Genetic Position: Chr1, 56.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91363
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 7 and 8, which encode part of the kinase domain. Sequencing of mRNA from the mutant allele confirmed lack of exons 7 and 8 and indicated a premature stop codon was created, thereby generating a truncated protein that contained only a part of the kinase domain. A transfection assay showed that mutant protein did not function as the wild-type. (J:91363)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbke Mutation:  25 strains or lines available
References
Original:  J:91363 Hemmi H, et al., The Roles of Two IkappaB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection. J Exp Med. 2004 Jun 21;199(12):1641-50
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory