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Bub1btm1Jvd
Targeted Allele Detail
Nomenclature
Symbol: Bub1btm1Jvd
Name: BUB1B, mitotic checkpoint serine/threonine kinase; targeted mutation 1, Jan M A van Deursen
MGI ID: MGI:3046580
Synonyms: Bub1bH, BubR1H
Gene: Bub1b  Location: Chr2:118428692-118472072 bp, + strand  Genetic Position: Chr2, 59.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91128
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation detailsA loxP site, neo cassette, and cryptic exon were inserted between exons 5 and 6 and a second loxP site inserted 5' of exon 5 via homologous recombination. Western blot analysis confirmed decreased protein expression from this hypomorphic allele. (J:91128)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bub1b Mutation:  49 strains or lines available
References
Original:  J:91128 Baker DJ, et al., BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 2004 Jul;36(7):744-9
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory