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Targeted Allele Detail
Symbol: Ungtm1Mend
Name: uracil DNA glycosylase; targeted mutation 1, Matthias Endres
MGI ID: MGI:3046503
Synonyms: Ung-
Gene: Ung  Location: Chr5:114130386-114139323 bp, + strand  Genetic Position: Chr5, 55.97 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:90910
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 - 3 and part of exon 4 were replaced with a neo cassette via homologous recombination. RT-PCR indicated that a transcript consisting of exons 1a and 6 is produced, however activity assays confirmed the absence of activity in homozygous cells. (J:90910)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ung Mutation:  17 strains or lines available
Original:  J:90910 Endres M, et al., Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest. 2004 Jun;113(12):1711-21
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory