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Tg(Igk-V21-Bax)1967Bvn
Transgene Detail
Nomenclature
Symbol: Tg(Igk-V21-Bax)1967Bvn
Name: transgene insertion 1967, Brian Van Ness
MGI ID: MGI:3046400
Synonyms: 3'KE-Bcl-XL, KE/Bcl-XL
Transgene: Tg(Igk-V21-Bax)1967Bvn  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of 3' enhancer and promoter sequence from the mouse Igk-V21, a flag epitope fused to mouse Bax cDNA, and the 3'UTR from the human growth hormone gene. The highest levels of expression of this transgene are found in the marrow, spleen and lymph nodes. Expression is also restricted to immature/transitional B cells. Three founder lines were generated 1962, 1967 and 2021. (J:89049)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:89049 Linden M, et al., Targeted overexpression of Bcl-XL in B-lymphoid cells results in lymphoproliferative disease and plasma cell malignancies. Blood. 2004 Apr 1;103(7):2779-86
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory