About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Ighatm1(Myc)Janz
Targeted Allele Detail
Nomenclature
Symbol: Ighatm1(Myc)Janz
Name: immunoglobulin heavy constant alpha; targeted mutation 1, Siegfried Janz
MGI ID: MGI:3046399
Synonyms: IgH-MycCα, IgH-MycCalpha, iMycCalpha
Gene: Igha  Location: Chr12:113256204-113260236 bp, - strand  Genetic Position: Chr12, 62.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90901
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Ighatm1(Myc)Janz expresses 1 gene
 
Mutation detailsA construct consisting of a 1.5 kb of segment of genomic 5' flanking sequence from the mouse Myc gene, the first noncoding exon with the P1/P2 promoters, a mouse Myc intron-less cDNA clone with an in-frame artificial histidine tag on the 3' end, a short segment of the 3' UTR including the major polyadenylationsite, and a loxP flanked neo cassettte was inserted in opposite transcriptional orientation into intron 1 of the C alpha locus via homologous recombination. The neo cassette was subsequently removed by mating to cre transgenic mice. (J:90901)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igha Mutation:  3 strains or lines available
References
Original:  J:90901 Cheung WC, et al., Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest. 2004 Jun;113(12):1763-73
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory