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Targeted Allele Detail
Symbol: Ighatm1(Myc)Janz
Name: immunoglobulin heavy constant alpha; targeted mutation 1, Siegfried Janz
MGI ID: MGI:3046399
Synonyms: IgH-MycCα, IgH-MycCalpha, iMycCalpha
Gene: Igha  Location: Chr12:113254830-113260236 bp, - strand  Genetic Position: Chr12, 62.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:90901
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
Ighatm1(Myc)Janz expresses 1 gene
Mutation detailsA construct consisting of a 1.5 kb of segment of genomic 5' flanking sequence from the mouse Myc gene, the first noncoding exon with the P1/P2 promoters, a mouse Myc intron-less cDNA clone with an in-frame artificial histidine tag on the 3' end, a short segment of the 3' UTR including the major polyadenylationsite, and a loxP flanked neo cassettte was inserted in opposite transcriptional orientation into intron 1 of the C alpha locus via homologous recombination. The neo cassette was subsequently removed by mating to cre transgenic mice. (J:90901)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igha Mutation:  3 strains or lines available
Original:  J:90901 Cheung WC, et al., Novel targeted deregulation of c-Myc cooperates with Bcl-X(L) to cause plasma cell neoplasms in mice. J Clin Invest. 2004 Jun;113(12):1763-73
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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