Mmp9^tm1Itoh
Targeted Allele Detail

Summary

• Symbol: Mmp9^tm1Itoh
• Name: matrix metallopeptidase 9; targeted mutation 1, Takeshi Itoh
• MGI ID: MGI:3046275
• Gene: Mmp9 Location: Chr2:164782700-164797770 bp, + strand Genetic Position: Chr2, 85.27 cM, cytoband H1-H2
• Alliance: Mmp9^tm1Itoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55823
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-6 were replaced by a neomycin selection cassette. A zymography assay demonstrated that no detectable activity of the encoded protein was present in lung lysates derived from homozygous mice. (J:55823)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mmp9 Mutation: 49 strains or lines available

References

• Original: J:55823 Itoh T, et al., Experimental metastasis is suppressed in MMP-9-deficient mice. Clin Exp Metastasis. 1999 Mar;17(2):177-81
• All: 4 reference(s)