About   Help   FAQ
Targeted Allele Detail
Symbol: Adgrv1tm1Pwh
Name: adhesion G protein-coupled receptor V1; targeted mutation 1, Perrin C White
MGI ID: MGI:3046273
Synonyms: Vlgr1del7TM, VLGR/delTM7
Gene: Adgrv1  Location: Chr13:81095068-81633154 bp, - strand  Genetic Position: Chr13, 42.18 cM
Germline Transmission:  Earliest citation of germline transmission: J:90899
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 691 bp segment including intron 81 and part of exon 82 was replaced with an HA tag, a 6xHis affinity purification tag, and a translation stop codon via homologous recombination. Western blot analysis confirmed expression of a single mutant protein. (J:90899)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adgrv1 Mutation:  166 strains or lines available
Original:  J:90899 McMillan DR, et al., Loss of the transmembrane and cytoplasmic domains of the very large G-protein-coupled receptor-1 (VLGR1 or Mass1) causes audiogenic seizures in mice. Mol Cell Neurosci. 2004 Jun;26(2):322-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory