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Adgrv1tm1Pwh
Targeted Allele Detail
Nomenclature
Symbol: Adgrv1tm1Pwh
Name: adhesion G protein-coupled receptor V1; targeted mutation 1, Perrin C White
MGI ID: MGI:3046273
Synonyms: Vlgr1del7TM, VLGR/delTM7
Gene: Adgrv1  Location: Chr13:81095068-81633154 bp, - strand  Genetic Position: Chr13, 42.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90899
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 691 bp segment including intron 81 and part of exon 82 was replaced with an HA tag, a 6xHis affinity purification tag, and a translation stop codon via homologous recombination. Western blot analysis confirmed expression of a single mutant protein. (J:90899)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adgrv1 Mutation:  166 strains or lines available
References
Original:  J:90899 McMillan DR, et al., Loss of the transmembrane and cytoplasmic domains of the very large G-protein-coupled receptor-1 (VLGR1 or Mass1) causes audiogenic seizures in mice. Mol Cell Neurosci. 2004 Jun;26(2):322-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory